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USC-OGP 2-DE database
Two-dimensional polyacrylamide gel electrophoresis database
USC-OGP 2-DE database
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World-2DPAGE Portal
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Searching in 'USC-OGP 2-DE database' for entry
matching:
P04632
USC-OGP 2-DE database
:
P04632
P04632
General information about the entry
View entry in simple text format
Entry name
CPNS1_HUMAN
Primary accession number
P04632
integrated into USC-OGP 2-DE database on
January 17, 2017 (release 1)
2D Annotations were last modified on
January 17, 2017 (version 1)
General Annotations were last modified on
April 5, 2017 (version 2)
Name and origin of the protein
Description
RecName: Full=Calpain small subunit 1; Short=CSS1; AltName: Full=Calcium-activated neutral proteinase small subunit; Short=CANP small subunit; AltName: Full=Calcium-dependent protease small subunit; Short=CDPS; AltName: Full=Calcium-dependent protease small subunit 1; AltName: Full=Calpain regulatory subunit;.
Gene name
Name=CAPNS1
Synonyms=CAPN4, CAPNS
Annotated species
Homo sapiens (Human) [TaxID:
9606
]
Taxonomy
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]
2D GEL CHARACTERIZATION
Author 1., Author 2.
Submitted (Mar-2011) to Current
2D PAGE maps for identified proteins
How to interpret a protein
PLATELET_4-5
{PLATELET 4-5}
Homo sapiens (Human)
map experimental info
PLATELET_4-5
MAP LOCATIONS:
SPOT OGP-0182
:
pI=4.94; Mw=26471
SPOT OGP-0248
:
pI=4.79; Mw=16912
UVEAL_MELANOMA_3-10
{UVEAL MELANOMA 3-10}
Homo sapiens (Human)
map experimental info
UVEAL_MELANOMA_3-10
MAP LOCATIONS:
SPOT OGP-1274
:
pI=6.07; Mw=27522
SPOT OGP-1275
:
pI=5.05; Mw=27445
SPOT OGP-1286
:
pI=6.01; Mw=25688
Cross-references
UniProtKB/Swiss-Prot
P04632; CPNS1_HUMAN.
2D PAGE maps for identified proteins
How to interpret a protein map
You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
Warning 1
: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
Warning 2
: the 2D PAGE map is built on demand. This may take some few seconds to be computed.
External data extracted from
UniProtKB/Swiss-Prot
Extracted from
UniProtKB/Swiss-Prot
, release:
0.0
Entry name
CPNS1_HUMAN
Primary accession number
P04632
Secondary accession number(s)
A8K0P1 Q8WTX3 Q96EW0
Sequence was last modified on
August 13, 1987 (version 1)
Annotations were last modified on
March 15, 2017 (version 192)
Name and origin of the protein
Description
RecName: Full=Calpain small subunit 1; Short=CSS1; AltName: Full=Calcium-activated neutral proteinase small subunit; Short=CANP small subunit; AltName: Full=Calcium-dependent protease small subunit; Short=CDPS; AltName: Full=Calcium-dependent protease small subunit 1; AltName: Full=Calpain regulatory subunit;
Gene name
Name=CAPNS1
Synonyms=CAPN4, CAPNS
Encoded on
Name=CAPNS1; Synonyms=CAPN4, CAPNS
Keywords
3D-structure
;
Acetylation
;
Calcium
;
Cell membrane
;
Complete proteome
;
Cytoplasm
;
Direct protein sequencing
;
Membrane
;
Metal-binding
;
Phosphoprotein
;
Polymorphism
;
Reference proteome
;
Repeat
.
Copyright
Copyrighted by the UniProt Consortium, see
http://www.uniprot.org/help/license
. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBL
X04106; CAA27726.1
; -; mRNA
EMBL
M31511; AAA35646.1
; -; Genomic_DNA
EMBL
M31502; AAA35646.1
; JOINED; Genomic_DNA
EMBL
M31503; AAA35646.1
; JOINED; Genomic_DNA
EMBL
M31504; AAA35646.1
; JOINED; Genomic_DNA
EMBL
M31505; AAA35646.1
; JOINED; Genomic_DNA
EMBL
M31506; AAA35646.1
; JOINED; Genomic_DNA
EMBL
M31507; AAA35646.1
; JOINED; Genomic_DNA
EMBL
M31508; AAA35646.1
; JOINED; Genomic_DNA
EMBL
M31509; AAA35646.1
; JOINED; Genomic_DNA
EMBL
M31510; AAA35646.1
; JOINED; Genomic_DNA
EMBL
AK289606; BAF82295.1
; -; mRNA
EMBL
BT009775; AAP88777.1
; -; mRNA
EMBL
AY789642; AAV40829.1
; -; Genomic_DNA
EMBL
AD001527; AAB51183.1
; -; Genomic_DNA
EMBL
AC002984; AAB81546.1
; -; Genomic_DNA
EMBL
BC000592; AAH00592.1
; -; mRNA
EMBL
BC007779; AAH07779.1
; -; mRNA
EMBL
BC011903; AAH11903.1
; -; mRNA
EMBL
BC017308; AAH17308.1
; -; mRNA
EMBL
BC018931; AAH18931.1
; -; mRNA
EMBL
BC021933; AAH21933.1
; -; mRNA
EMBL
BC023643; AAH23643.1
; -; mRNA
EMBL
BC064998; AAH64998.1
; -; mRNA
CCDS
CCDS12489.1; -
; .
PIR
A26107; CIHUL
; .
RefSeq
NP_001003962.1; NM_001003962.2
; .
RefSeq
NP_001289561.1; NM_001302632.1
; .
RefSeq
NP_001289562.1; NM_001302633.1
; .
RefSeq
NP_001740.1; NM_001749.3
; .
RefSeq
XP_005259352.1; XM_005259295.1
; .
RefSeq
XP_005259353.1; XM_005259296.1
; .
UniGene
Hs.515371; -
; .
PDB
1KFU; X-ray
; 2.50 A; S=85-268
PDB
1KFX; X-ray
; 3.15 A; S=85-268
PDB
4PHJ; X-ray
; 1.60 A; A/B=96-268
PDB
4PHK; X-ray
; 2.05 A; A/B=96-268
PDB
4PHM; X-ray
; 2.03 A; A/B=96-268
PDB
4WQ2; X-ray
; 1.64 A; A/B=96-268
PDB
4WQ3; X-ray
; 1.79 A; A/B=96-268
PDB
5D69; X-ray
; 1.97 A; A/B=96-268
PDBsum
1KFU; -
; .
PDBsum
1KFX; -
; .
PDBsum
4PHJ; -
; .
PDBsum
4PHK; -
; .
PDBsum
4PHM; -
; .
PDBsum
4WQ2; -
; .
PDBsum
4WQ3; -
; .
PDBsum
5D69; -
; .
ProteinModelPortal
P04632; -
; .
SMR
P04632; -
; .
BioGrid
107276; 59
; .
IntAct
P04632; 25
; .
MINT
MINT-5000880; -
; .
STRING
9606.ENSP00000246533; -
; .
BindingDB
P04632; -
; .
ChEMBL
CHEMBL2111357; -
; .
DrugBank
DB02570; PD150606
; .
iPTMnet
P04632; -
; .
PhosphoSitePlus
P04632; -
; .
SwissPalm
P04632; -
; .
BioMuta
CAPNS1; -
; .
DMDM
115612; -
; .
OGP
P04632; -
; .
REPRODUCTION-2DPAGE
IPI00025084; -
; .
SWISS-2DPAGE
P04632; -
; .
EPD
P04632; -
; .
MaxQB
P04632; -
; .
PaxDb
P04632; -
; .
PeptideAtlas
P04632; -
; .
PRIDE
P04632; -
; .
TopDownProteomics
P04632; -
; .
DNASU
826; -
; .
Ensembl
ENST00000246533; ENSP00000246533
; ENSG00000126247; .
Ensembl
ENST00000588815; ENSP00000464849
; ENSG00000126247; .
GeneID
826; -
; .
KEGG
hsa:826; -
; .
UCSC
uc002odi.2; human
; .
CTD
826; -
; .
DisGeNET
826; -
; .
GeneCards
CAPNS1; -
; .
HGNC
HGNC:1481; CAPNS1
; .
HPA
HPA006872; -
; .
MIM
114170; gene
; .
neXtProt
NX_P04632; -
; .
OpenTargets
ENSG00000126247; -
; .
PharmGKB
PA26067; -
; .
eggNOG
KOG0037; Eukaryota
; .
eggNOG
ENOG410YKQK; LUCA
; .
GeneTree
ENSGT00620000087734; -
; .
HOGENOM
HOG000063658; -
; .
HOVERGEN
HBG004492; -
; .
InParanoid
P04632; -
; .
KO
K08583; -
; .
PhylomeDB
P04632; -
; .
TreeFam
TF314682; -
; .
BRENDA
3.4.22.53; 2681
; .
BRENDA
3.4.22.B24; 2681
; .
Reactome
R-HSA-1474228; Degradation of the extracellular matrix
; .
Reactome
R-HSA-6809371; Formation of the cornified envelope
; .
Reactome
R-HSA-8862803; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
; .
ChiTaRS
CAPNS1; human
; .
EvolutionaryTrace
P04632; -
; .
GeneWiki
CAPNS1; -
; .
GenomeRNAi
826; -
; .
PRO
PR:P04632; -
; .
Proteomes
UP000005640; Chromosome 19
; .
Bgee
ENSG00000126247; -
; .
CleanEx
HS_CAPNS1; -
; .
ExpressionAtlas
P04632; baseline and differential
; .
Genevisible
P04632; HS
; .
GO
GO:0005829; C:cytosol
; IDA:BHF-UCL; .
GO
GO:0070062; C:extracellular exosome
; IDA:UniProtKB; .
GO
GO:0016020; C:membrane
; IDA:BHF-UCL; .
GO
GO:0005886; C:plasma membrane
; TAS:Reactome; .
GO
GO:0005509; F:calcium ion binding
; IEA:InterPro; .
GO
GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity
; TAS:ProtInc; .
GO
GO:0004175; F:endopeptidase activity
; TAS:Reactome; .
GO
GO:0070268; P:cornification
; TAS:Reactome; .
GO
GO:0022617; P:extracellular matrix disassembly
; TAS:Reactome; .
GO
GO:0008284; P:positive regulation of cell proliferation
; TAS:ProtInc; .
GO
GO:0016241; P:regulation of macroautophagy
; NAS:ParkinsonsUK-UCL; .
CDD
cd00051; EFh
; 1; .
Gene3D
1.10.238.10; -
; 1; .
InterPro
IPR011992; EF-hand-dom_pair
; .
InterPro
IPR018247; EF_Hand_1_Ca_BS
; .
InterPro
IPR002048; EF_hand_dom
; .
Pfam
PF13202; EF-hand_5
; 1; .
Pfam
PF13833; EF-hand_8
; 1; .
SUPFAM
SSF47473; SSF47473
; 1; .
PROSITE
PS00018; EF_HAND_1
; 2; .
PROSITE
PS50222; EF_HAND_2
; 3; .
Gateways to other related servers
The World-2DPAGE Constellation
- Entry point to the world-wide 2-DPAGE resources.
World-2DPAGE Repository
- A public repository for gel-based proteomics data linked to protein identification published in the literature.
World-2DPAGE Portal
- A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
SWISS-2DPAGE
- The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
ExPASy
- The resources web server of the
Swiss Institute of Bioinformatics
Database constructed and maintained by
Angel Garcia
, using the
Make2D-DB II
package (
ver. 3.10.2
) from the
World-2DPAGE Constellation
of the
ExPASy web server
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